Lipfle is a monophasic cross-linked hyaluronic acid lip filler from HJ Corporation at 24 mg/ml, supplied in a 1.2 ml syringe with a 24-month shelf life and made from non-animal sources. Besides HA, it includes PDRN, vitamin B12, and mannitol. The manufacturer positions it for lip volume, definition, and hydration, placed by a professional.

What is Lipfle, and what is in it?

Lipfle is a hyaluronic acid (HA) lip filler. HA is a moisture-binding sugar your body already makes, and cross-linking helps the gel hold shape over time. Lipfle is monophasic, a single smooth gel phase, listed at 24 mg/ml in a 1.2 ml syringe with a 24-month shelf life and a non-animal source.

What makes it distinctive is the supporting cast. Alongside HA, the manufacturer lists three added ingredients. Vitamin B12, which the maker says can give lips a temporary reddish hue. PDRN, a salmon-DNA fragment that is reported to support tissue regeneration, calm inflammation, and encourage collagen. And mannitol, an antioxidant and humectant reported to help hydrate and plump. These are described by the manufacturer as supportive ingredients, not proven outcomes.

Log Notes. This page explains what Lipfle is and what its maker reports. It gives no doses, depths, injection points, mixing steps, or technique, all of which belong to a licensed professional and the official guide. Nothing here is medical advice, and lip filling is not a do-it-yourself procedure.

How are PDRN, B12, and mannitol described?

As reported supports, not guarantees. PDRN (polydeoxyribonucleotide) is the most-discussed of the three. It is a fragmented DNA molecule, often salmon-derived, that is studied and marketed for tissue repair and a calming, regenerative effect. If you want the fuller picture of that ingredient on its own, our note on PDRN walks through what the research does and does not show.

The honest framing matters here. Vitamin B12’s red tint is a cosmetic, temporary effect the manufacturer describes, not a clinical claim. Mannitol’s antioxidant and humectant role is reported for the ingredient class. None of this is the same as proven results for Lipfle specifically, since newer combination products tend to be less independently studied than their individual parts. Dermal fillers in general are placed in soft tissue to add or restore volume, and reputable patient-facing summaries describe HA fillers as temporary and gradually absorbed (Cleveland Clinic, dermal fillers).

What should you expect, and what is worth tracking?

A defined window. The manufacturer reports immediate results that last roughly three to six months, which is typical for HA lip products as they slowly break down. Because the effect fades on a timeline, the useful question is not “how do my lips look today” but “how are they trending across the months,” and that is where a dated record earns its keep.

That is exactly what Dosefi is built for. You add Lipfle as a treatment, log each session with its date and a photo, set a reminder near the three-to-six-month review window, and self-rate volume, shape, and hydration so the fade is visible in your own data rather than a vague feeling. A log keeps your history honest; it never makes a procedure safe.

If you are comparing lip and facial options, our overview of a body-positioned gel like Foxy Fill shows how different scale and use case can be, and any decision about Lipfle itself belongs with a qualified professional.

A grounded takeaway

Lipfle is a 24 mg/ml monophasic HA lip filler with PDRN, vitamin B12, and mannitol as reported supporting ingredients, positioned for lip volume, definition, and hydration with results the maker reports at about three to six months. Treat the ingredient claims as reported, keep a dated record, and leave candidacy and the procedure to a licensed professional. The official guide is attached for your reference.

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